Recombinant Human C6/complement component 6 Protein (His Tag)

CAT: 0763-PKSH030844Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0763-PKSH030844Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, pp46 and GAP43, is a cell membrane protein which belongs to theneuromodulin family. Neuromodulin / GAP43 contains oneIQ domain. Neuromodulin / GAP43 is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Neuromodulin / GAP43 is involved in neurite outgrowth, a crucial process for the differentiation of neurons. The sudden infant death syndrome (SIDS) is the main cause of postneonatal infant death and its cause is still unknown. Neuromodulin / GAP43 is a marker of synaptic plasticity and is critical for normal development of the serotonergic innervation. Neuromodulin / GAP43 is a major cortical cytoskeleton-associated and calmodulin binding protein that is widely and abundantly expressed during development, maintained in selected brain structures in the adult, and reinduced during nerve regeneration. CAP23 and GAP43 are functionally related intrinsic determinants of anatomical plasticity. These proteins function by locally promoting subplasmalemmal actin cytoskeleton accumulation.

Synonyms

UniProt

P13671

Accession Number

AAA59668.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Ala 934

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

104 kDa

Observed Molecular Weight

110 kDa

Species

Human

UniProtKB · P13671

Complement component C6

CO6_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P13671
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: C6
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: —

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Complement pathwayCytolysisImmunityInnate immunity

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainRepeatSignalSushiTransmembraneTransmembrane beta strand

Cellular component

MembraneMembrane attack complexSecretedTarget cell membraneTarget membrane

Product Datasheet

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