Recombinant Human FABP3 Protein

CAT: 0763-PKSH030830Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0763-PKSH030830Size:100 µg

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Background

Fatty acid binding protein 3 (FABP3; also termed heart-type fatty acid binding protein) is a member of the intracellular lipid-binding protein family that may be essential in fatty acid transport; cell growth; cellular signaling and gene transcription. Previously FABP3 was involved in apoptosis-associated congenital cardiac malformations. FABP3 knockdown exhibited significant toxic effects on cardiac development and mitochondrial function; which may be responsible for the knockdown of FABP3-induced apoptosis. FABP3 as a candidate gene underlying the etiology of congenital heart defects. Overexpression of FABP3 inhibited cell growth and proliferation via negative regulation of the cell cycle and down-regulation of cell growth factors; but enhances cell survival in hypoxic or ischemic conditions. FABPs are known to be carrier proteins for transporting fatty acids and other lipophilic substances from the cytoplasm to the nucleus; where these lipids are released to a group of nuclear receptors such as peroxisome proliferator-activated receptors (PPARs) .

Synonyms

FABP11; FABP3; Fatty Acid-Binding Protein 3; Fatty Acid-Binding Protein Heart; H-FABP; Heart-Type Fatty Acid-Binding Protein; M-FABP; MDGI; MDGIMuscle Fatty Acid-Binding Protein; Mammary-Derived Growth Inhibitor; O-FABP

UniProt

P05413

Accession Number

P05413

Expression System

E.coli

Tag

None

Sequence

Met 1-Ala 133

Field of Research

Signal Transduction; Cardiovascular; Cancer; metabolism

Endotoxin

Please contact us for more information.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

14.9 kDa

Species

Human

UniProtKB · P05413

Fatty acid-binding protein, heart

FABPH_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P05413
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: FABP3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B2RAB6, Q5VV93, Q99957

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Cellular component

Cytoplasm

Ligand

Lipid-binding

Biological process

Transport

Product Datasheet

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Alternative Products

Catalog	Name
ARP2072-01	Recombinant Human FABP3 Protein
PPT-12607	Human FABP3 Recombinant Protein
TMPY-02239-01	FABP3 Protein, Human, Recombinant
RP011158	FABP3 Recombinant Protein (Human)
167825-01	FABP3, Recombinant, Human, (human FABP3, h-FABP3, rh-FABP3, FABP-3, FABP3, FABP 3, Fatty Acid Binding Protein 3, recombinant human FABP3, recombinant FABP3, FABP) discontinued
OPCD03040-50UG	FABP3 Recombinant Protein