Recombinant Human FABP3 Protein

• Background:

  Fatty acid binding protein 3 (FABP3; also termed heart-type fatty acid binding protein) is a member of the intracellular lipid-binding protein family that may be essential in fatty acid transport; cell growth; cellular signaling and gene transcription. Previously FABP3 was involved in apoptosis-associated congenital cardiac malformations. FABP3 knockdown exhibited significant toxic effects on cardiac development and mitochondrial function; which may be responsible for the knockdown of FABP3-induced apoptosis. FABP3 as a candidate gene underlying the etiology of congenital heart defects. Overexpression of FABP3 inhibited cell growth and proliferation via negative regulation of the cell cycle and down-regulation of cell growth factors; but enhances cell survival in hypoxic or ischemic conditions. FABPs are known to be carrier proteins for transporting fatty acids and other lipophilic substances from the cytoplasm to the nucleus; where these lipids are released to a group of nuclear receptors such as peroxisome proliferator-activated receptors (PPARs) .

• Synonyms:

  FABP11; FABP3; Fatty Acid-Binding Protein 3; Fatty Acid-Binding Protein Heart; H-FABP; Heart-Type Fatty Acid-Binding Protein; M-FABP; MDGI; MDGIMuscle Fatty Acid-Binding Protein; Mammary-Derived Growth Inhibitor; O-FABP

• UniProt:

  P05413

• Accession Number:

  P05413

• Expression System:

  E.coli

• Tag:

  None

• Sequence:

  Met 1-Ala 133

• Field of Research:

  Signal Transduction; Cardiovascular; Cancer; metabolism

• Endotoxin:

  Please contact us for more information.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  14.9 kDa

• Species:

  Human