Recombinant Rat IL-4 Protein

• Background:

  Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.

• Abbreviation:

  IL-4

• Synonyms:

  Interleukin; B-cell growth factor; B-cell stimulatory factor; Lymphocyte stimulatory factor; BCGF1; B-cell IGG differentiation factor; B-cell stimulatory factor 1; BCGF-1; Binetrakin; BSF1; Interleukin-4; Lymphocyte stimulatory factor 1; Pitrakinra; Il4; BSF-1; Lymphocy; Il 4; B-cell growth factor 1; Il-4; IL4、BCGF-1、BCGF1、BSF-1、BSF1

• UniProt:

  P20096

• Accession Number:

  P20096

• Expression System:

  HEK293 Cells

• Tag:

  C-His

• Sequence:

  Met1-Ser147

• Field of Research:

  Cancer; Cardiovascular; Immunology

• Endotoxin:

  < 1.0 EU/mg of the protein as determined by the LAL method.

• Purity:

  > 90% as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  16.5 kDa

• Observed Molecular Weight:

  17 kDa

• Species:

  Rat