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Recombinant Human IL-4 Protein

CAT: 0763-PDEH100723-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0763-PDEH100723-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
Abbreviation
IL-4
Synonyms
Interleukin; B-cell growth factor; BSF; IL4; BCGF-1; BCGF1; BSF-1; BSF1; IL-4; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; Binetrakin; IGG1 induction factor; Interleukin-4; Lymphocyte stimulatory factor 1; Pitrakinra
UniProt
P05112
Accession Number
P05112
Expression System
E.coli
Tag
N-His
Sequence
His25-Ser153
Field of Research
Cancer; Cardiovascular; Immunology
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
15 kDa
Observed Molecular Weight
16 kDa
Species
Human

UniProtKB · P05112

Interleukin-4

IL4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05112
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-4
EC number
—
Processing
Precursor
Secondary accessions
Q14630, Q6NZ77
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

B-cell activation

Molecular function

CytokineGrowth factor

PTM

Disulfide bondGlycoprotein

Cellular component

Secreted

Domain

Signal

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