TCMCB07 (TFA)

• UNSPSC Description:

  TCMCB07 TFA, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 TFA plays an important role in cachexia[1].

• Target Antigen:

  Melanocortin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/tcmcb07-tfa.html

• Purity:

  99.69

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  N/C(N)=N/CCC[C@@H](C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](C(NC(C(N3[C@@H](C(N)=O)CCC3)=O)C(C)C)=O)CCCCNC(C[C@@H]4NC([C@H](CCCC)NC(C)=O)=O)=O)=O)=O)NC([C@@H](CC5=CC=C(C=CC=C6)C6=C5)NC([C@H](CCC7)N7C4=O)=O)=O.OC(C(F)(F)F)=O.[x]

• Molecular Weight:

  1230.46 (free base)

• References & Citations:

  [1]Yongjun Hu, et al. Characterization of the cellular transport mechanisms for the anti-cachexia candidate compound TCMCB07. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1677-1687.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  Phase 1