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NPHS1 Polyclonal Antibody

CAT: 0763-E-AB-70211-01Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-70211-01Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180-kDa protein in lysates of human glomeruli and a 150-kDa protein in transfected COS-7 cell lysates.
Abbreviation
NPHS1
UniProt
Q9QZS7
Host
Rabbit
Reactivity
Mouse
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse Nephrin
Target
CNF; Nephrin; Nephrosis 1 congenital Finnish type; Nephrosis 1; congenital; Finnish type (nephrin) ; NPHN; NPHN; NPHS 1; Nphs1; Renal glomerulus specific cell adhesion receptor; Renal glomerulus-specific cell adhesion receptor
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Signal Transduction
Purification
Affinity purification
Concentration
1.3 mg/mL
Dilution
IHC 1:1000-1:2000
Buffer
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG
Product Datasheet
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