NPHS2 Polyclonal Antibody

• Background:

  This gene encodes the glomerular protein podocin which plays a role in the regulation of glomerular permeability, and acts as a linker between the plasma membrane and the cytoskeleton. Defects in this gene are the cause of autosomal recessive steroid-resistant nephrotic syndrome (SRN) . SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease. An alternative splice variant has been described but its full length sequence has not been determined.

• Abbreviation:

  NPHS2

• UniProt:

  Q9NP85

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthetic peptide of human NPHS2

• Target:

  Nephrosis 2; idiopathic; steroid resistant (podocin) ; nephrosis 2; idiopathic; steroid resistant; NPHS2; NPHS2 gene; PDCN; PODO; Podocin; SRN1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  IHC

• Field of Research:

  Cancer; Cell biology; Signal transduction; Tags and Cell markers

• Purification:

  Affinity purification

• Concentration:

  1.4 mg/mL

• Dilution:

  IHC 1:50-1:200

• Buffer:

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Citation 01:

  https://www.tandfonline.com/doi/abs/10.1080/1354750X.2022.2157489

• Isotype:

  IgG