BAP1 Polyclonal Antibody

• Background:

  This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.

• Abbreviation:

  BAP1

• UniProt:

  Q92560

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Recombinant fusion protein of human BAP1 (NP_004647.1) .

• Target:

  BAP1; HUCEP-13; UCHL2; hucep-6

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC; IF

• Field of Research:

  Cancer; Cell Biology; Epigenetics and Nuclear Signaling

• Purification:

  Affinity purification

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  80kDa

• Observed Molecular Weight:

  80kDa

• Isotype:

  IgG