HUS1 Polyclonal Antibody

• Background:

  The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.

• Abbreviation:

  HUS1

• UniProt:

  O60921

• Host:

  Rabbit

• Reactivity:

  Human; Mouse

• Immunogen:

  Fusion protein of human HUS1

• Target:

  Checkpoint protein HUS1; hHUS1; HUS1 (S. pombe) checkpoint homolog; Hus1; HUS1 checkpoint homolog (S. pombe) ; HUS1 Checkpoint Protein; HUS1 protein; HUS1+ - like protein; HUS1; Hydroxyurea-sensitive 1; S. pombe; homolog of

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  IHC

• Field of Research:

  Cancer; Epigenetics and Nuclear Signaling

• Purification:

  Antigen affinity purification

• Concentration:

  0.78 mg/mL

• Dilution:

  IHC 1:40-1:200

• Buffer:

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype:

  IgG