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EDARADD Polyclonal Antibody

CAT: 0763-E-AB-52310-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-52310-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Abbreviation
EDARADD
UniProt
Q8WWZ3
Host
Rabbit
Reactivity
Human
Immunogen
Full length fusion protein
Target
Cr; Crinkled homolog; ectodysplasia A receptor associated death domain; Ectodysplasin-A receptor-associated adapter protein; ED3; EDA3; EDAD; EDAR associated death domain; EDAR-associated death domain protein; EDARADD; Protein crinkled homolog
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Epigenetics and Nuclear Signaling; Developmental biology; Signal transduction
Purification
Antigen affinity purification
Concentration
0.9 mg/mL
Dilution
IHC 1:35-1:200
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

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