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FNDC3B Polyclonal Antibody

CAT: 0763-E-AB-52260-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-52260-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1,204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration.
Abbreviation
FNDC3B
UniProt
Q53EP0
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Full length fusion protein
Target
DKFZp686D14170 ; DKFZp762K137; Factor for adipocyte differentiation 104; FAD104; fibronectin type III domain containing 3B ; FLJ23399; HCV NS5A binding protein 37 ; MGC10002; NS5ABP37; PRO4979; YVTM2421
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Metabolism; Signal transduction; Stem cells
Purification
Antigen affinity purification
Concentration
1.8 mg/mL
Dilution
IHC 1:30-1:150
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · Q53EP0

Fibronectin type III domain-containing protein 3B

FND3B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q53EP0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FNDC3B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2RB36, B3KXR8, D3DNQ7, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Membrane

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

RepeatTransmembraneTransmembrane helix

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