NR0B2 Polyclonal Antibody

CAT: 0763-E-AB-52169-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0763-E-AB-52169-01Size:20 µL
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Abbreviation
NR0B2
UniProt
Q15466
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Fusion protein of human NR0B2
Target
NR0B2; NR0B2; Nr0b2a; Nuclear receptor subfamily 0 group B member 2; Nuclear receptor subfamily 0; group B; member 2a; Orphan nuclear receptor SHP; SHP; SHP-1; Shp1; Small heterodimer partner
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling; Metabolism; Signal transduction
Purification
Antigen affinity purification
Concentration
0.6 mg/mL
Dilution
IHC 1:30-1:150
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

Popular Products