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CXCL12/SDF1 Polyclonal Antibody

CAT: 0763-E-AB-40578-01Size: 25 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-40578-01Size:25 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The stromal cell derived factor 1 (SDF1/CXCL12) is a small, pro-inflammatory chemoattractant cytokine that regulates leukocyte trafficking through interactions with its cognate 7-transmembrane G protein-coupled receptors. The SDF1/CXCL12 receptor, CXCR4, also serves as a coreceptor for the entry of human immunodeficiency virus into target cells. SDF1/CXCL12 may regulate homing and maintenance of CXCR4-expressing stem or progenitor cells, including embryonic and many somatic stem cells. Many cancer cells express CXCR4, suggesting that SDF1/CXCL12 plays a role in cancer metastasis. Alternative splicing and differential processing during maturation produce a pair of SDF1/CXCL12 isoforms (SDF1/CXCL12α and SDF1/CXCL12β) that have different properties and biological activities. Additional isoforms of SDF1/CXCL12 have been reported.
Abbreviation
CXCL12
UniProt
Q9QZD1
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Rat CXCL12 protein expressed by E.coli.
Target
Cxcl12; SDF-1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Immunology; Microbiology; Cardiovascular
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:2000-4000
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
10kDa
Observed Molecular Weight
10kDa
Isotype
IgG

UniProtKB · Q9QZD1

Stromal cell-derived factor 1

Q9QZD1_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
Q9QZD1
Review status
UniProtKB unreviewed (TrEMBL)
Gene
Cxcl12
Protein existence
2: Evidence at transcript level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Biological process

Chemotaxis

Molecular function

CytokineGrowth factor

PTM

Disulfide bond

Cellular component

Secreted

Domain

Signal

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