Α-SMA Polyclonal Antibody

• Background :

  Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. ACTA2 (Actin, Alpha 2, Smooth Muscle, Aorta) is a Protein Coding gene. Diseases associated with ACTA2 include Multisystemic Smooth Muscle Dysfunction Syndrome and Moyamoya Disease 5. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and GPCR Pathway. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is ACTG2. ACTA1 (Actin, Alpha 1, Skeletal Muscle) is a Protein Coding gene. Diseases associated with ACTA1 include Nemaline Myopathy 3, Autosomal Dominant Or Recessive and Myopathy, Congenital, With Fiber-Type Disproportion. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and GPCR Pathway. GO annotations related to this gene include structural constituent of cytoskeleton and myosin binding. An important paralog of this gene is ACTC1. ACTG2 (Actin, Gamma 2, Smooth Muscle, Enteric) is a Protein Coding gene. Diseases associated with ACTG2 include Visceral Myopathy and Chronic Intestinal Pseudoobstruction. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and GPCR Pathway. An important paralog of this gene is ACTA2.

• Abbreviation :

  Α-SMA

• UniProt :

  P62736, P68133, P63267

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from α-SMA

• Target :

  A actin; AAT6; ACTA; ACTA2; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; Actin; aortic smooth muscle; ACTSA; ACTVS; Alpha 2 actin; Alpha actin 2; Alpha cardiac actin; alpha sma; Alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; GIG46; Growth inhibiting gene 46; MYMY5; ACTC; ACTC; ACTC1; Actin alpha cardiac muscle 1; Actin; alpha cardiac muscle 1; Alpha-cardiac actin; ASD5; CMD1R; CMH11; LVNC4; a actin; Actin alpha skeletal muscle; Actin; actin; alpha 1; skeletal muscle 1; actin; alpha 1; skeletal muscle; Actin; alpha skeletal muscle; actina; actine; ACTS; aktin; Alpha Actin 1; ; ASMA; CFTD; CFTD1; CFTDM; MPFD; NEM1; NEM2; NEM3; nemaline myopathy type 3

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC-p; IF

• Field of Research :

  Cancer; Cardiovascular; Developmental Biology; Signal Transduction; Stem Cells

• Purification :

  Affinity purification

• Concentration :

  1 mg/mL

• Dilution :

  WB 1:500-2000; IHC 1:50-300; IF 1:50-1:200

• Buffer :

  PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  42kDa

• Observed Molecular Weight :

  42kDa

• Citation 01 :

  https://www.nature.com/articles/s41467-022-30464-8

• Citation 02 :

  https://www.sciencedirect.com/science/article/pii/S0141813022026228

• Citation 03 :

  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068511/

• Citation 04 :

  https://www.sciencedirect.com/science/article/pii/S002432052200577X

• Citation 05 :

  https://www.sciencedirect.com/science/article/pii/S0024320522009560

• Citation 06 :

  https://www.mdpi.com/2150366

• Citation 07 :

  https://www.mdpi.com/2073-4409/8/11/1435

• Citation 08 :

  https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.5081

• Citation 09 :

  https://www.mdpi.com/1587758

• Citation 10 :

  https://www.sciencedirect.com/science/article/pii/S0022030223000644

• Citation 11 :

  https://www.tandfonline.com/doi/abs/10.1080/21655979.2021.1954580

• Citation 12 :

  https://jpet.aspetjournals.org/content/364/3/399.abstract

• Isotype :

  IgG