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CBFA2T2 Polyclonal Antibody

CAT: 0763-E-AB-19075-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-19075-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
In acute myeloid leukemia, especially in the M2 subtype, the t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Abbreviation
CBFA2T2
UniProt
O43439
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Fusion protein of human CBFA2T2
Target
AML1 MTG8; cbfa2t2; Core binding factor runt domain alpha subunit 2 translocated to 2; core-binding factor; runt domain; alpha subunit 2; DKFZp313F2116; EHT; ETO homolog on chromosome 20; ETO homologous on chromosome 20; MTG 8 like protein; MTG 8 related protein 1; MTG8 like protein; MTG8 related protein 1; MTG8-like protein; MTG8-related protein 1; MTG8R; MTGR 1; Myeloid translocation gene related protein 1; Myeloid translocation related protein 1; Myeloid translocation-related protein 1; p85; Protein CBFA2T2; ZMYND 3; ZMYND3
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Tags; Cell Markers
Purification
Antigen affinity purification
Concentration
1.26 mg/mL
Dilution
WB 1:1000-1:5000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
67 kDa
Observed Molecular Weight
Refer to figures
Isotype
IgG

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