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SETMAR Polyclonal Antibody

CAT: 0763-E-AB-18994-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-18994-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants.
Abbreviation
SETMAR
UniProt
Q53H47
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Fusion protein of human SETMAR
Target
Histone lysine N methyltransferase; Histone lysine N methyltransferase SETMAR; Hsmar 1; Hsmar1; Mariner transposase Hsmar1; Metnase; SET domain and mariner transposase fusion; SET domain and mariner transposase fusion gene; SET domain and mariner transposase fusion gene containing protein; SET domain and mariner transposase fusion gene-containing protein; Setmar; SETMR
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Epigenetics and Nuclear Signaling
Purification
Antigen affinity purification
Concentration
1.08 mg/mL
Dilution
IHC 1:50-1:300
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · Q53H47

Histone-lysine N-methyltransferase SETMAR

SETMR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q53H47
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SETMAR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DY74, E7EN68, Q13579, Q1G668, Q96F41
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Chromatin regulatorDNA-bindingEndonucleaseHydrolaseMethyltransferaseMultifunctional enzymeNucleaseTransferase

Cellular component

ChromosomeNucleus

Biological process

DNA damageDNA repair

Ligand

MagnesiumMetal-bindingS-adenosyl-L-methionineZinc

PTM

MethylationPhosphoprotein

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