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EARS2 Polyclonal Antibody

CAT: 0763-E-AB-18191-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-18191-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12) . Alternative splicing results in multiple transcript variants.
Abbreviation
EARS2
UniProt
Q5JPH6
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthetic peptide of human EARS2
Target
3230401I01Rik; AL024049; COXPD12; EARS 2; ears2; GluRS; Glutamate--tRNA ligase; Glutamyl tRNA synthetase 2 mitochondrial; mitochondrial; mKIAA1970; MSE1; Probable glutamyl tRNA synthetase; mitochondrial ; Probable glutamyl-tRNA synthetase; RGD1307904; SYEM
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Epigenetics and Nuclear Signaling; Metabolism; Signal transduction
Purification
Antigen affinity purification
Concentration
0.9 mg/mL
Dilution
IHC 1:50-1:100
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · Q5JPH6

Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

SYEM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q5JPH6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EARS2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
6.1.1.24
Processing
Precursor
Secondary accessions
B3KTT2, D3DWF1, Q86YH3, Q8TF31
Protein keywords

PTM

Acetylation

Coding sequence diversity

Alternative splicing

Molecular function

Aminoacyl-tRNA synthetaseLigaseRNA-binding

Ligand

ATP-bindingNucleotide-binding

Disease

Disease variantPrimary mitochondrial disease

Cellular component

Mitochondrion

Biological process

Protein biosynthesis

Technical term

Proteomics identificationReference proteome

Domain

Transit peptide

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