TXNIP Polyclonal Antibody

CAT: 0763-E-AB-17496-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0763-E-AB-17496-01Size:20 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) .
Abbreviation
TXNIP
UniProt
Q9H3M7
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human TXNIP
Target
THIF; VDUP1; HHCPA78; EST01027
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Cell biology; Epigenetics and Nuclear Signaling; Metabolism; Signal transduction
Purification
Affinity purification
Concentration
1.9 mg/mL
Dilution
IHC 1:30-150
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

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