PNOC Polyclonal Antibody

CAT: 0763-E-AB-16651-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0763-E-AB-16651-01Size:20 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Nociception, a pain response mechanism, occurs in response to stimuli that threaten the integrity of an organism. The first synapses produced as a result of the initiation of nociception are modulated by excitatory amino acids (glutamate and aspartate) and many peptides (substance P, CGRP, CCK, endogenous opioids) . Nociceptin (also designated orphanin FQ) is a neuronal peptide that is similar to opioid peptides. Nociceptin activates KOR-3 (kappa-type opioid receptor, also designated ORL1), a G protein-coupled receptor. Although similar to dynorphin A, a kappa opioid peptide, nociceptin functions to make animals hyperreactive to nociceptive stimulations. Nociceptin is also involved in locomotor behavior and may be involved in the modulation of synaptic plasticity in learning and memory.
Abbreviation
PNOC
UniProt
Q13519
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of human PNOC
Target
N/OFQ; N23K; N23K/N27K; Nociceptin; included; nocistatin; Npnc1; OFQ; OFQ/N; Orphanin FQ; Orphanin FQ2; Pnoc; PNOC; ppN/OFQ; PPNOC; pre-pro-N/OFQ; prepronociceptin; pronociceptin; Propronociceptin
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Neuroscience
Purification
Affinity purification
Concentration
0.4 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

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