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STAT2 Polyclonal Antibody

CAT: 0763-E-AB-16244-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-16244-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.
Abbreviation
STAT2
UniProt
P52630
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of human STAT2
Target
Homo sapiens interferon alpha induced transcriptional activator; interferon alpha induced transcriptional activator; ISGF 3; ISGF3; MGC59816; P113; signal transducer and activator of transcription 2 113kD; Signal transducer and activator of transcription 2; STAT113; Stat2; STAT2
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling; Signal Transduction
Purification
Affinity purification
Concentration
0.5 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
98kDa
Isotype
IgG

UniProtKB · P52630

Signal transducer and activator of transcription 2

STAT2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P52630
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
STAT2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DLC7, G3V2M6, Q16430, Q16431, Q9UDL4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseHost-virus interactionTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Disease variant

PTM

PhosphoproteinUbl conjugation

Domain

SH2 domain

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CatalogName
JOT-AP14533-01STAT2 Polyclonal Antibody

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