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DSP Polyclonal Antibody

CAT: 0763-E-AB-15605-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-15605-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
Abbreviation
DSP
UniProt
P15924
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthetic peptide of human DSP
Target
250/210 kDa paraneoplastic pemphigus antigen; DCWHKTA; Desmoplakin (DPI DPII) ; Desmoplakin; Desmoplakin I; Desmoplakin II; DESP; DP; DP I; DP II; DPI; DPII; DSP; KPPS2; PPKS 2; PPKS2
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Signal Transduction
Purification
Affinity purification
Concentration
1 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P15924

Desmoplakin

DESP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15924
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DSP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
DP
EC number
—
Processing
—
Secondary accessions
B2RTT2, D7RX09, O75993, Q14189, Q9UHN4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

CardiomyopathyDisease variantEpidermolysis bullosaHypotrichosisPalmoplantar keratoderma

Cellular component

Cell junctionCell membraneCell projectionCytoplasmMembraneNucleus

Domain

Coiled coilRepeatSH3 domain

Molecular function

DNA-binding

PTM

MethylationPhosphoprotein

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