DAB2 Polyclonal Antibody

• Background :

  This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• Abbreviation :

  DAB2

• UniProt :

  P98082

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Recombinant protein of human DAB2

• Target :

  DAB 2; Dab; mitogen-responsive phosphoprotein; homolog 2 (Drosophila) ; DAB2; Differentially expressed in ovarian cancer 2; Differentially expressed protein 2; Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein) ; Disabled homolog 2; Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila) ; Disabled homolog 2 mitogen responsive phosphoprotein; Disabled; Drosophila; homolog of;2; DOC 2; DOC2; FLJ26626; Mitogen responsive phosphoprotein

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC

• Field of Research :

  Cancer; Epigenetics and Nuclear Signaling; Signal Transduction

• Purification :

  Affinity purification

• Concentration :

  0.6 mg/mL

• Dilution :

  WB 1:500-1:2000; IHC 1:50-1:200

• Buffer :

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  82kDa

• Isotype :

  IgG