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ACVR2A Polyclonal Antibody

CAT: 0763-E-AB-14487-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0763-E-AB-14487-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Abbreviation
ACVR2A
UniProt
P27037
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human ACVR2A
Target
Activin A receptor type IIA; Activin receptor type 2A; Activin receptor type IIA; Activin receptor type-2A; ACTR 2; ACTR IIA; ACTR-IIA; ACTR2; ACTRII; ACTRIIA; Acvr 2; Acvr 2A; Acvr2; ACVR2A; AVR2A; OTTHUMP00000197918
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Metabolism; Signal Transduction; Stem Cells
Purification
Affinity purification
Concentration
0.2 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
58kDa
Citation 01
https://onlinelibrary.wiley.com/doi/abs/10.1002/dta.2346
Isotype
IgG

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