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VWA5A Polyclonal Antibody

CAT: 0763-E-AB-10998-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-10998-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A.
Abbreviation
VWA5A
UniProt
O00534
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant protein of human VWA5A
Target
BCSC1; BCSC-1; LOH11CR2A
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Purification
Affinity purification
Concentration
0.9 mg/mL
Dilution
IHC 1:100-1:300
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · O00534

von Willebrand factor A domain-containing protein 5A

VMA5A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00534
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
VWA5A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6UN19, Q6UN20, Q9BVF8
Protein keywords

Coding sequence diversity

Alternative splicing

Technical term

Proteomics identificationReference proteome

Disease

Tumor suppressor

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