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AANAT Polyclonal Antibody

CAT: 0763-E-AB-10969-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-10969-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Abbreviation
AANAT
UniProt
Q16613
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human AANAT
Target
AA-NAT; Aanat; Aralkylamine N-acetyltransferase; Arylalkylamine N acetyltransferase; Serotonin acetylase; Serotonin N-acetyltransferase; SNAT; SNAT
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Metabolism; Neuroscience
Purification
Affinity purification
Concentration
0.6 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · Q16613

Serotonin N-acetyltransferase

SNAT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16613
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AANAT
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Serotonin acetylase
EC number
2.3.1.87
Processing
—
Secondary accessions
A0AVF2, J3KMZ5, Q562F4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

AcyltransferaseTransferase

Coding sequence diversity

Alternative splicing

Biological process

Biological rhythmsMelatonin biosynthesis

Cellular component

Cytoplasm

PTM

Phosphoprotein

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