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MUTYH Polyclonal Antibody

CAT: 0763-E-AB-10477-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-10477-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Abbreviation
MUTYH
UniProt
Q9UIF7
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant protein of human MUTYH
Target
A/G specific adenine DNA glycosylase; A/G-specific adenine DNA glycosylase; Adenine DNA glycosylase; CYP2C; hMYH; MGC4416; MutY (E. coli) homolog; MutY homolog (E. coli) ; MutY homolog; MutY; E. coli; homolog of; Mutyh; MUTYH; MYH; rMYH
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Affinity purification
Concentration
0.3 mg/mL
Dilution
WB 1:1000-1:5000; IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
60kDa
Isotype
IgG

UniProtKB · Q9UIF7

Adenine DNA glycosylase

MUTYH_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UIF7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MUTYH
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.2.2.31
Processing
—
Secondary accessions
D3DPZ4, Q15830, Q9UBP2, Q9UBS7, Q9UIF4, Q9UIF5, Q9UIF6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

4Fe-4SIronIron-sulfurMetal-binding

Coding sequence diversity

Alternative splicing

Disease

Disease variantTumor suppressor

Biological process

DNA damageDNA repair

Molecular function

GlycosidaseHydrolase

Cellular component

MitochondrionNucleus

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