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APEX1 Polyclonal Antibody

CAT: 0763-E-AB-10130-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-10130-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
Abbreviation
APEX1
UniProt
P27695
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human APEX1
Target
AP endonuclease 1; AP endonuclease class I; AP lyase; APE 1; APE; APE-1; APEN; APEX 1; APEX; APEX nuclease (multifunctional DNA repair enzyme) 1; Apex nuclease 1; APEX nuclease; APEX1; APEX1; Apurinic endonuclease; Apurinic-apyrimidinic endonuclease 1; Apurinic/apyrimidinic (abasic) endonuclease; Apurinic/apyrimidinic endonuclease 1; Apurinic/apyrimidinic exonuclease; APX; BAP1; Deoxyribonuclease (apurinic or apyrimidinic) ; DNA (apurinic or apyrimidinic site) lyase; DNA- (apurinic or apyrimidinic site) lyase; mitochondrial; EC 4.2.99.18; HAP 1; HAP1; Human Apurinic endonuclease 1; MGC139790; Multifunctional DNA repair enzyme; Redox factor 1; Redox factor-1; REF 1; REF 1 protein; REF-1; REF1; REF1 protein
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Cardiovascular; Epigenetics and Nuclear Signaling
Purification
Affinity purification
Concentration
0.1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
36kDa
Isotype
IgG

UniProtKB · P27695

DNA repair nuclease/redox regulator APEX1

APEX1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P27695
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
APEX1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.11.2, 3.1.21.-
Processing
—
Secondary accessions
Q969L5, Q99775
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationCleavage on pair of basic residuesDisulfide bondPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

ActivatorDNA-bindingEndonucleaseExonucleaseHydrolaseNucleaseRepressorRNA-binding

Cellular component

CytoplasmEndoplasmic reticulumMitochondrionNucleus

Biological process

DNA damageDNA recombinationDNA repairTranscriptionTranscription regulation

Ligand

MagnesiumMetal-binding

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