Products for Research Use Only
RegisterLogin

MS15 (TFA)

CAT: 0804-HY-151613A-01Size: 1 mgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-151613A-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MS15 TFA is a potent and selective AKT PROTAC degrader. MS15 TFA inhibits the AKT1, -2, and -3 activities, with IC50 values of 798 nM, 90 nM, and 544 nM, respectively[1].
UNSPSC
12352005
Target
Akt; PROTACs
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms15-tfa.html
Purity
99.86
Solubility
DMSO : ≥ 100 mg/mL
Smiles
NC1(CCC1)C(C=C2)=CC=C2N3C4=NC(C5=CC(CCC(NCCCCCCCCCCC(N[C@H](C(N6C[C@@H](C[C@H]6C(N[C@@H](C)C7=CC=C(C=C7)C8=C(N=CS8)C)=O)O)=O)C(C)(C)C)=O)=O)=CC=C5)=CC=C4N=C3C9=CC=CN=C9N.OC(C(F)(F)F)=O
Molecular Formula
C66H80F3N11O7S
Molecular Weight
1228.47
References & Citations
[1]Yu X, et al. Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells. J Med Chem. 2022 Oct 27;65 (20) :14237-14260.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light, stored under nitrogen
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-151613-01MS15
HY-P5380ATNO211 (TFA)
HY-P4668A-01Valylleucine (TFA)
HY-P11296A-01LLVK (TFA)
HY-P10927A-01BRP (TFA)
HY-P10333A-01LIH383 (TFA)
HY-P3970D-01KQFK (TFA)
HY-P3460A-01TDSRCVIGLYHPPLQVY (TFA)
HY-P1723ASpexin (TFA)
HY-P10471A-01MPSD (TFA)

Alternative Products

CatalogName
GTR19231286-01MS15 TFA
A23975-5MS15 TFA 5mg
A23975-50MS15 TFA 50mg
A23975-10MS15 TFA 10mg
A23975-1MS15 TFA 1mg
MBS5816906MS15
MS15LIDBRPMS15 lid fitted with Buffer Recirculation Ports (No cables)
MS15STLID-BRPMS15 Stretch lid fitted with Buffer Recirculation Ports (No cables)
A8967-1EZM0414 TFA
C8651-10Pentosidine TFA

Popular Products