Rel-Boc-Hyp-OMe

• Description :

  Rel-Boc-Hyp-OMe is the isomer of Boc-Hyp-OMe (HY-65039), and can be used as an experimental control. Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  ADC Linker; PROTAC Linkers

• Type :

  Reference compound

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/rel-boc-hyp-ome.html

• Purity :

  99.74

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1[C@H](C(OC)=O)C[C@@H](O)C1)OC(C)(C)C

• Molecular Formula :

  C11H19NO5

• Molecular Weight :

  245.27

• Precautions :

  H315, H319

• References & Citations :

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1145663-09-7]