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Fmoc-Hyp (Bom) -OH

CAT: 0804-HY-79125Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-79125Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fmoc-Hyp (Bom) -OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Fmoc-Hyp (Bom) -OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<
CAS Number
187223-15-0
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fmoc-hyp-bom-oh.html
Purity
99.85
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@@H]1C[C@@H](OC(NCCNC(OC(C)(C)C)=O)=O)CN1C(OCC2C3=C(C=CC=C3)C4=C2C=CC=C4)=O
Molecular Formula
C28H33N3O8
Molecular Weight
539.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker

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