YKL-05-093

CAT: 0804-HY-101149Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-101149Size:1 Each

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Description

YKL-05-093 is a salt-induced kinase (SIK) inhibitor (SIK2: Kd = 7.1 nM) . YKL-05-093 reduces the phosphorylation level of HDAC4/5/CRTC2, inhibits SOST expression, and stimulates RANKL expression in vitro and in vivo. YKL-05-093 can be used in research on bone diseases[1].

CAS Number

2172616-44-1

UNSPSC

12352005

Target

HDAC; RANKL/RANK ; Salt-inducible Kinase (SIK)

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; NF-κB

Field of Research

Inflammation/Immunology

Smiles

O=C1N(C2=CC=C(C=C2OC)OC)C3=NC(NC4=CC=C(C5CCN(CC5)C)C(OC)=C4)=NC=C3CN1C6=C(C)C=CC=C6C

Molecular Formula

C35H40N6O4

Molecular Weight

608.73

References & Citations

[1]Wein MN, et al. SIKs control osteocyte responses to parathyroid hormone. Nat Commun. 2016 Oct 19;7:13176.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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