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RecombinantIL-1β, Rat

CAT: 0013-GTR18990517-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18990517-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin-1 Beta (IL-1 Beta) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta bind to the same receptor and have similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.Recombinant rat Interleukin-1 Beta (rat IL-1 Beta) produced in E.coli is a single non-glycosylated polypeptide chain containing 152 amino acids. A fully biologically active molecule, recombinant rat IL-1 Beta protein has a molecular mass of 17.3kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Product Name Alternative
Interleukin-1β; IL-1β; Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF), IL1F2, IL-1 beta.
Source
Escherichia coli.
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% by SDS-PAGE and HPLC analyses.
Bioactivity
ED50 1.0x 10ˆ8 units/mg.
Form
Lyophilized after extensive dialysis against PBS.
Molecular Weight
17.3 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant rat Interleukin-1 Beta (IL-1 Beta) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, recombinant rat IL-1 Beta should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O at 100 μg/ml.
Preservative
Lyophilized after extensive dialysis against PBS.
AA Sequence
VPI RQLHCRLRDE QQKCLVLSDP CELKALHLNG QNISQQVVFS MSFVQGETSN DKIPVALGLK GLNLYLSCVM KDGTPTLQLE SVDPKQYPKK KMEKRFVFNK IEVKTKVEFE SAQFPNWYIS TSQAEHRPVF LGNSNGRDIV DFTMEPVSS

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