Products for Research Use Only
RegisterLogin

RecombinantIL-21, Human

CAT: 0013-GTR18990516-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR18990516-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Interleukin-21 (IL-21) belongs to the Type I four helix bundle cytokines, and shares the common cytokine receptor γ chain with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells, and the IL-21 receptor is highly expressed on CD4+ and CD8+ B cells; indeed, IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells. IL-21 up-regulates and down-regulates the production of IgG1 and IgE by B cells, respectively, and diminishes the severity of allergy and asthma. In some case, IL-21 also induces the apoptosis of B cells. The other roles of IL-21 include regulation of innate immune systems, implication on autoimmunity, and antitumor actions.Recombinant human Interleukin-21 (rhIL-21) produced in E.coli is a single non-glycosylated polypeptide chain containing 132 amino acids. A fully biologically active molecule, rhIL-21 has a molecular mass of 15.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Product Name Alternative
Interleukin-21, IL21
Source
Escherichia coli.
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% by SDS-PAGE analysis.
Bioactivity
ED50 2.0x 10ˆ6 units/mg.
Form
Lyophilized after extensive dialysis against PBS.
Molecular Weight
15.4 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant human Interleukin-21 (rhIL-21) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhIL-21 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O at 100 μg/mL.
Preservative
Lyophilized after extensive dialysis against PBS.
AA Sequence
MQDRHMIRM RQLIDIVDQL KNYVNDLVPE FLPAPEDVET NCEWSAFSCF QKAQLKSANT GNNERIINVS IKKLKRKPPS TNAGRRQKHR LTCPSCDSYE KKPPKEFLER FKSLLQKMIH QHLSSRTHGS EDS

Related Products

CatalogName
GTR18990515-01RecombinantIL-21, Mouse
GTR18990520-01RecombinantIL-1β, Human
GTR18990514-01RecombinantIL-22, Human
GTR18990302-01RecombinantIL-2, Human
GTR18990297-01RecombinantIL-4, Human
GTR18990287-01RecombinantIL-6R, Human
GTR18990282-01RecombinantIL-9, Human
GTR18990509-01RecombinantIL-33, Human
GTR18990507-01RecombinantIL-5, Human
GTR18990227-01RecombinantIL-4R, Human

Alternative Products

CatalogName
BK0098RecombinantIL-21,Human
BK0098-01RecombinantIL-21, Human
BK0109RecombinantIL-6,Human
BK0236-01RecombinantIL-18BP, Human
BK0240-01RecombinantIL-2, Human
BK0100-01RecombinantIL-22, Human
BK0316RecombinantIL-4R,Human
BK0240RecombinantIL-2,Human
BK0259RecombinantIL-9,Human
BK0104RecombinantIL-33,Human

Popular Products