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RecombinantOSM (209aa), Human

CAT: 0013-GTR18990472-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18990472-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and shares a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor β or LIF Receptor β to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells. Recombinant human Oncostatin M (209 a.a.) (rhOSM) produced in E. coli is a single non-glycosylated polypeptide chain containing 210 amino acids. A fully biologically active molecule, rhOSM has a molecular mass of 23.8 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Product Name Alternative
Oncostatin M
Source
Escherichia coli.
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE and HPLC.
Bioactivity
ED50 1x 10ˆ5 units/mg.
Form
Lyophilized after extensive dialysis against PBS.
Molecular Weight
23.8 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant human Oncostatin M (209 a.a.) (rhOSM) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhOSM should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O or PBS at 100 μg/ml.
Preservative
Lyophilized after extensive dialysis against PBS.
AA Sequence
MAAIGSCSK EYRVLLGQLQ KQTDLMQDTS RLLDPYIRIQ GLDVPKLREH CRERPGAFPS EETLRGLGRR GFLQTLNATL GCVLHRLADL EQRLPKAQDL ERSGLNIEDL EKLQMARPNI LGLRNNIYCM AQLLDNSDTA EPTKAGRGAS QPPTPTPASD AFQRKLEGCR FLHGYHRFMH SVGRVFSKWG ESPNRSRRHS PHQALRKGVR R

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