SCH-34826

• UNSPSC Description:

  SCH-34826 is an orally active neutral metalloendopeptidase (NEP) inhibitor that inhibits NEP and reduces the degradation of ANF, thereby enhancing its antihypertensive and diuretic effects. SCH-34826 can be used in the research of cardiovascular and renal diseases[1].

• Target Antigen:

  Neprilysin

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cardiovascular Disease; Others

• Assay Protocol:

  https://www.medchemexpress.com/sch-34826.html

• Smiles:

  O=C(O)CCNC([C@H](CC1=CC=CC=C1)NC(CC2=CC=CC=C2)C(OCC3OC(C)(C)OC3)=O)=O

• Molecular Weight:

  498.57

• References & Citations:

  [1]Sybertz E J, et al. Atrial natriuretic factor-potentiating and antihypertensive activity of SCH 34826. An orally active neutral metalloendopeptidase inhibitor[J]. Hypertension, 1990, 15(2): 152-161.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 2

• CAS Number:

  105262-04-2