11(α)-Methoxysaikosaponin F

• UNSPSC Description:

  11(α)-Methoxysaikosaponin F is a triterpenoid saponin isolated from Bupleurum marginatum Wall.ex DC(ZYCH) which is a promising therapeutic for liver fibrosis. 11(α)-Methoxysaikosaponin F has an IC50 of 387.7 nM with viability of hepatic stellate cells-T6 (HSCs-T6). Triterpenoid saponins have numerous targets, important network positions, and strong inhibitory activity[1].

• Target Antigen:

  Others

• Type:

  Natural Products

• Related Pathways:

  Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/11-alpha-methoxysaikosaponin-f.html

• Purity:

  99.51

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  C[C@]12[C@@]([C@@H](C=C3[C@]2(C[C@H](O)[C@]4(CO)[C@@]3([H])CC(C)(C)CC4)C)OC)([H])[C@@]5([C@@](C(C)([C@@H](O[C@]6([H])O[C@@H]([C@@H](O[C@@]7([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O7)O)O)[C@H](O)[C@H]6O)CO[C@@H]8O[C@@H]([C@@H](O)[C@H](O)[C@H]8O)CO)CC5)C)([H])CC1)C

• Molecular Weight:

  959.16

• References & Citations:

  [1]Liu X, et al. Bupleurum marginatum Wall.ex DC in Liver Fibrosis: Pharmacological Evaluation, Differential Proteomics, and Network Pharmacology. Front Pharmacol. 2018 May 17;9:524.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  104109-37-7