Anti-Transcription factor MafB MAFB Antibody

• Description:

  Boster Bio Anti-Transcription factor MafB MAFB Antibody catalog # A02446. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Transcription factor MafB; Maf-B; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B; MAFB; KRML;

• Gene Name:

  MAFB

• UniProt:

  Q9Y5Q3

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein of human MAFB.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Ubiquitous.

• Applications:

  WB

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Dilution:

  WB: 1:500-1:2000

• Form:

  Liquid

• Function:

  Acts as a transcriptional activator or repressor (PubMed:27181683) . Plays a pivotal role in regulating lineage- specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity) . Involved either as an oncogene or as a tumor suppressor, depending on the cell context.

• Molecular Weight:

  35792 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Transcription factor MafB

• Subcellular Location:

  Nucleus

• Protein Name:

  Transcription factor MafB