Anti-Transcription factor RFX3 RFX3 Antibody

• Description:

  Boster Bio Anti-Transcription factor RFX3 RFX3 Antibody catalog # A07674. Tested in WB applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Transcription factor RFX3; Regulatory factor X 3; RFX3

• Gene Name:

  RFX3

• UniProt:

  P48380

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human RFX3. AA range:641-690

• Clonality:

  Polyclonal

• Applications:

  WB

• Purification:

  Immunogen affinity purified

• Dilution:

  WB, 1:500-1:2000

• Form:

  Liquid

• Function:

  Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left- right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity) . Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032) . Represses transcription of MAP1A in non- neuronal cells but not in neuronal cells (PubMed:12411430) . .

• Molecular Weight:

  83530 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Transcription factor RFX3

• Subcellular Location:

  Nucleus .