CUDC-427

• UNSPSC Description:

  CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers.

• Target Antigen:

  IAP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CUDC-427.html

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C([C@H](CCC1)N1C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)NC3=C(C4=CC=CC=C4)N=C(C5=NC=CO5)S3

• Molecular Weight:

  564.70

• References & Citations:

  [1]Wong H, et al. Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist. Drug Metab Dispos. 2013 Dec;41(12):2104-13.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Phase 1

• CAS Number:

  1446182-94-0