PHT-427

• Description:

  PHT-247 is an inhibitor of the pleckstrin homology (PH) domain of Akt, and it is also an inhibitor of PDPK1 with Kis of 2.7 μM and 5.2 μM and for Akt and PDPK1, respectively.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H320, H335

• Target:

  Akt; Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/PHT-427.html

• Purity:

  99.09

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  CCCCCCCCCCCCC1=CC=C(C=C1)S(NC2=NN=CS2)(=O)=O

• Molecular Formula:

  C20H31N3O2S2

• Molecular Weight:

  409.61

• Precautions:

  H302, H315, H320, H335

• References & Citations:

  [1]Meuillet EJ, et al. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar;9 (3) :706-17.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1191951-57-1