PHT-427

CAT: 0804-HY-12063-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12063-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PHT-247 is an inhibitor of the pleckstrin homology (PH) domain of Akt, and it is also an inhibitor of PDPK1 with Kis of 2.7 μM and 5.2 μM and for Akt and PDPK1, respectively.
CAS Number
[1191951-57-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
Akt; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PHT-427.html
Purity
99.09
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCC1=CC=C(C=C1)S(NC2=NN=CS2)(=O)=O
Molecular Formula
C20H31N3O2S2
Molecular Weight
409.61
Precautions
H302, H315, H320, H335
References & Citations
[1]Meuillet EJ, et al. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar;9 (3) :706-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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