Human TNR11 protein (Active)

CAT: 0013-GTR18881633-01Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18881633-01Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

This Human TNR11 protein (Active) spans the amino acid sequence from region 29-202aa. Purity: > 98% as determined by SDS-PAGE and HPLC.

Product Name Alternative

Osteoclast differentiation factor receptor, Receptor activator of NF-KB, CD antigen CD265

UniProt

Q9Y6Q6

Expression Region

29-202aa

Tag

Tag-Free

Source

E.Coli

Origin

Homo sapiens (Human)

Field of Research

Cancer Biology

Endotoxin

Less than 1.0 EU/μg as determined by LAL method.

Purity

> 98% as determined by SDS-PAGE and HPLC.

Bioactivity

Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit sRANK Ligand induced nuclear factor kappa B (NFkappaB) in RAW 264.7 cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 x 10 ^ 4 IU/mg in the presence of 15 ng/ml of recombinant sRANK Ligand.

Form

Lyophilized powder

Molecular Weight

19.1 kDa

Storage Conditions

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

For research use only.

Applications Notes

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Preservative

Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, pH 8.0, 150mM NaCl

AA Sequence

QIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVCSSSLPARK

UniProtKB · Q9Y6Q6

Tumor necrosis factor receptor superfamily member 11A

TNR11_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9Y6Q6
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: TNFRSF11A
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: I4EC36, I4EC38, I4EC39, I7JE63, N0GVH0, Q59EP9

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

Disease

DeafnessDisease variantOsteopetrosis

PTM

Disulfide bondGlycoproteinPhosphoprotein

Ligand

Metal-bindingSodium

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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