Malachite green (hemioxalate) (Standard)

• UNSPSC Description:

  Malachite green (hemioxalate) (Standard) is the analytical standard of Malachite green (hemioxalate). This product is intended for research and analytical applications. Malachite green hemioxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo[1][2][3].

• Target Antigen:

  Apoptosis; IKK; NF-κB

• Type:

  Reference Standards

• Related Pathways:

  Apoptosis;NF-κB

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/malachite-green-hemioxalate-standard.html

• Smiles:

  C/[N+](C)=C1C=C/C(C=C/1)=C(C2=CC=C(N(C)C)C=C2)\C3=CC=CC=C3.O=C(O)C([O-])=O.O=C(O)C(O)=O.[1/2]

• Molecular Weight:

  463.50

• References & Citations:

  [1]Kozuka S, et, al. Permeability of dormant spores of Bacillus subtilis to malachite green and crystal violet. J Gen Microbiol. 1991 Mar; 137(3): 607-13.|[2]Takahashi S, et, al. Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells. J Am Chem Soc. 2012 Dec 5; 134(48): 19588-91.|[3]Liu T, et, al. Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE. Cytokine. 2019 Apr; 116: 78-87.

• Shipping Conditions:

  Room temperature

• CAS Number:

  2437-29-8