1-Deoxymannojirimycin (hydrochloride)

1-Deoxymannojirimycin (hydrochloride)

• CAS Number: 73465-43-7
• UNSPSC Description: 1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity[1][2].
• Target Antigen: HIV; Influenza Virus
• Type: Natural Products
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/1-deoxymannojirimycin-hydrochloride.html
• Purity: 99.06
• Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
• Smiles: O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)NC1.Cl
• Molecular Weight: 199.63
• References & Citations: [1]F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98.|[2]Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported