1-Deoxynojirimycin (hydrochloride)

• UNSPSC Description:

  1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

• Target Antigen:

  Antibiotic; Bacterial; Glycosidase; PI3K

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease;PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Infection; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/1-deoxynojirimycin-hydrochloride.html

• Solubility:

  H2O : 250 mg/mL (ultrasonic)

• Smiles:

  O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O.[H]Cl

• Molecular Weight:

  199.63

• References & Citations:

  [1]Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600.|[2]Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232.|[3]Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20(12):21700-14.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Phase 2

• CAS Number:

  73285-50-4