OTOG rabbit pAb

• Background:

  The protein encoded by this gene is a component of the acellular membranes of the inner ear. Disruption of the orthologous mouse gene shows that it plays a role in auditory and vestibular functions. It is involved in fibrillar network organization, the anchoring of otoconial membranes and cupulae to the neuroepithelia, and likely in sound stimulation resistance. Mutations in this gene cause autosomal recessive nonsyndromic deafness, type 18B. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

• Description:

  The protein encoded by this gene is a component of the acellular membranes of the inner ear. Disruption of the orthologous mouse gene shows that it plays a role in auditory and vestibular functions. It is involved in fibrillar network organization, the anchoring of otoconial membranes and cupulae to the neuroepithelia, and likely in sound stimulation resistance. Mutations in this gene cause autosomal recessive nonsyndromic deafness, type 18B. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014],

• Gene ID:

  340990

• UniProt:

  Q6ZRI0

• Cellular Locus:

  Apical cell membrane ; Peripheral membrane protein ; Extracellular side. Secreted, extracellular space. Found in fiber-like structures during the maturation process of the tectorial membrane..

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse

• Reactivity:

  Human; Mouse

• Immunogen:

  Synthesized peptide derived from human OTOG AA range: 2706-2756

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  IHC, IF

• Validated Applications:

  IHC, IF

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  IHC-p 1: 50-200

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Subcellular Location:

  Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Secreted, extracellular space . Found in fiber-like structures during the maturation process of the tectorial membrane. .

• Gene ID (Human):

  340990

• SwissProt (Human):

  Q6ZRI0