LY 3000328

• Description :

  LY 3000328 (Z-FL-COCHO) is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for hCat S and mCat S, respectively.

• Product Name Alternative :

  Z-FL-COCHO

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Cathepsin

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/LY-3000328.html

• Concentration :

  10mM

• Purity :

  99.50

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  O=C(C1=CC=C(F)C=C1)N[C@@H]2[C@@H](OC(NC)=O)COC3=CC=C(N4CCN(C5COC5)CC4)C=C32

• Molecular Formula :

  C25H29FN4O5

• Molecular Weight :

  484.52

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Jadhav PK, et al. Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm. ACS Med Chem Lett. 2014 Aug 27;5 (10) :1138-42.|[2]Payne CD, et al. Pharmacokinetics and pharmacodynamics of the cathepsin S inhibitor, LY3000328, in healthy subjects. Br J Clin Pharmacol. 2014 Dec;78 (6) :1334-42.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  Cathepsin S

• CAS Number :

  [1373215-15-6]