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IOX1

CAT: 0804-HY-12304-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-12304-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IOX1, a chemical probe, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC50 values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively[1][2]. IOX1 also inhibits ALKBH5[3].
CAS Number
5852-78-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IOX1.html
Purity
99.89
Solubility
DMSO : 13.33 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=C2C=CC=NC2=C(O)C=C1)O
Molecular Formula
C10H7NO3
Molecular Weight
189.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Schiller R, et al. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9 (3) :566-71.|[2]Hu Q, et al. IOX1, a JMJD2A inhibitor, suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II by regulating the expression of cell cycle-related proteins. Int J Mol Med. 2016 Jan;37 (1) :189-96.|[3]Li F, et al. A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5. Biomol Screen. 2016 Mar;21 (3) :290-7.|[4]Yuan Deng, et al. Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression. J Biol Chem
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM2; KDM3; KDM4; KDM6

Chemical Information

8-Hydroxy-5-quinolinecarboxylic acid

8-hydroxy-5-quinolinecarboxylic acid is a member of quinolines.

CAS Number5852-78-8
PubChem CID459617
IUPAC Name8-hydroxyquinoline-5-carboxylic acid
Molecular FormulaC10H7NO3
Molecular Weight189.17
XLogP1.8
Topological Polar Surface Area70.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count14
Formal Charge0
Complexity231
SMILES
C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O
InChI
InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
InChIKey
JGRPKOGHYBAVMW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 8-Hydroxy-5-quinolinecarboxylic acid
CAS: 5852-78-8
CID: 459617
Formula: C10H7NO3
MW: 189.17
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight189.17
XLogP31.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass189.042593085
Monoisotopic Mass189.042593085
Topological Polar Surface Area70.4 Ų
Heavy Atom Count14
Formal Charge0
Complexity231
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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