RegisterLogin

IOX2 (sodium)

CAT: 0804-HY-15468ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-15468ASize:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
IOX2 sodium is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 sodium regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 sodium can be used in the study of thrombotic diseases[1][2].
CAS Number
[2377239-85-3]
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/iox2-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C(O[Na])CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O
Molecular Formula
C19H15N2NaO5
Molecular Weight
374.32
References & Citations
[1]Gu W, et al. Inhibition of Hypoxia-Inducible Factor Prolyl-Hydroxylase Modulates Platelet Function. Thromb Haemost. 2022 Oct;122 (10) :1693-1705. |[2]Deppe J, et al. Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90 (5) :1141-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-15468-01IOX2
HY-16268A-01Kartogenin (sodium)
HY-B1637-01Ditiocarb sodium
HY-Y1326-01Sodium metabisulfite
HY-145727A-01Volanesorsen (sodium)
HY-132584A-01Casimersen (sodium)
HY-132598A-01Miravirsen (sodium)
HY-14664A-01Fluvastatin (sodium)
HY-B1257-01Cefmetazole (sodium)
HY-153496ASepofarsen (sodium)

Alternative Products

CatalogName
sc-482692AIOX2
A4189-5.1IOX2(Glycine)
BUP22411-01IOX2-NH2-1
T206026-01IOX2-NH2-Methyl
bs-66054C-01IOX2, HIF Prolyl-Hydroxylases (PHD2) Inhibitor
1191110 1Sodium Metabisulphite (Sodium Disulphite, Sodium Pyrosulphite)
21121001Sodium caprylate- (Sodium octanoate)
RM-T081600-01Thiopental Sodium And Sodium Carbonate
31112-22Sodium
030180-01Sodium Metabisulphite (Sodium Disulphite, Sodium Pyrosulphite) 95.0%

Popular Products