RegisterLogin

IOX2

CAT: 0804-HY-15468-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15468-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
IOX2, a chemical probe, is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 can be used in the study of thrombotic diseases[1][2].
CAS Number
[931398-72-0]
UNSPSC
12352005
Hazard Statement
H301
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IOX2.html
Purity
99.71
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O)CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O
Molecular Formula
C19H16N2O5
Molecular Weight
352.34
Precautions
H301
References & Citations
[1]Deppe J, et al. Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90 (5) :1141-50.|[2]Gu W, et al. Inhibition of Hypoxia-Inducible Factor Prolyl-Hydroxylase Modulates Platelet Function. Thromb Haemost. 2022 Oct;122 (10) :1693-1705.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-12304-01IOX1
HY-158341-01IOX5
HY-120110-01IOX4

Alternative Products

CatalogName
sc-482692AIOX2
A4189-SIOX2(Glycine)
BUP22411-01IOX2-NH2-1
T206026-01IOX2-NH2-Methyl
bs-66054C-01IOX2, HIF Prolyl-Hydroxylases (PHD2) Inhibitor

Popular Products