Products for Research Use Only
RegisterLogin

IOX5

CAT: 0804-HY-158341-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-158341-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
IOX5 is a selective prolyl hydroxylase (PHD) inhibitor with an IC50 of 0.19 μM for PHD2. IOX5 stabilizes HIF-1α in acute myeloid leukemia (AML) cells, inhibits cell proliferation and induces apoptosis. IOX5 has anti-leukemia activity[1].
UNSPSC
12352005
Target
Apoptosis; HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iox5.html
Purity
99.39
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(F)([C@H]1CC[C@H](CNC(C2=CNC(N3N=CC=C3)=CC2=O)=O)CC1)F
Molecular Formula
C17H19F3N4O2
Molecular Weight
368.35
References & Citations
[1]Lawson H, et al. The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia. Nat Cancer. 2024 Apr 18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-12304-01IOX1
HY-15468-01IOX2
HY-120110-01IOX4
HY-15468AIOX2 (sodium)

Alternative Products

CatalogName
GTR19262364-01IOX5

Popular Products